Early marker for Alzheimer’s disease: Hippocampus T1rho (T1ρ ) estimation
نویسندگان
چکیده
M. Haris, E. McArdle, M. Sochor, M. Fenty, A. Singh, C. Davatzikos, J. Q. Trojanowski, E. R. Melhem, C. M. Clark, R. Reddy, and A. Borthakur MMRRCC, Radiology, University of Pennsylvania, Philadephia, PA, United States, SBIA, Radiology, University of Pennsylvania, Philadephia, PA, United States, Department of Pathology & Lab Medicine, University of Pennsylvania, Philadephia, PA, United States, Radiology, University of Pennsylvania, Philadephia, PA, United States, Department of Neurology, University of Pennsylvania, Philadephia, PA, United States
منابع مشابه
T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease
In the current study, we have evaluated the performance of magnetic resonance (MR) T1rho (T1ρ) imaging and CSF biomarkers (T-tau, P-tau and Aβ-42) in characterization of Alzheimer's disease (AD) patients from mild cognitive impairment (MCI) and control subjects. With informed consent, AD (n = 27), MCI (n = 17) and control (n = 17) subjects underwent a standardized clinical assessment and brain ...
متن کاملT1ρ MRI of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia in the elderly. Classic symptoms of the disease include memory loss and confusion associated with the hallmark neuro-pathologic lesions of neurofibrillary tangles (NFT) and senile plaques (SP) and their sequelae, gray matter atrophy. Volumetric assessment methods measure tissue atrophy, which typically follows early biochemical change...
متن کاملBi-phase age-related brain gray matter magnetic resonance T1rho relaxation time change
Objectives: To investigate normative value and age-related change of brain magnetic resonance T1ρ relaxation at 1.5T. range: 21-62 years), were scanned at 1.5 Tesla using 3D fluid suppressed turbo spin echo sequence. Regions-of-interests (ROIs) were obtained by atlas-based tissue segmentation and T1ρ was calculated by fitting the mean value to mono-exponential model. Correlation between T1ρ rel...
متن کاملEarly marker for Alzheimer's disease: hippocampus T1rho (T(1rho)) estimation.
PURPOSE To evaluate the T1rho (T(1rho)) MRI relaxation time in hippocampus in the brain of Alzheimer's disease (AD), mild cognitive impairment (MCI), and control, and to determine whether the T(1rho) shows any significant difference between these cohorts. MATERIALS AND METHODS With informed consent, AD (n = 49), MCI (n = 48), and age-matched control (n = 31) underwent T(1rho) MRI on a Siemens...
متن کاملComparison of T1rho and T2 Mapping of Knee Articular Cartilage in an Asymptomatic Population
OBJECTIVE To analyze subregional differences in T1rho (T1ρ) and T2 values and their correlation in asymptomatic knee cartilage, and to evaluate angular dependence with magic angles. MATERIALS AND METHODS Six asymptomatic volunteers underwent knee MRI with T1ρ and T2 mapping. T1ρ and T2 values were measured by two radiologists independently, at nine subregions in the medial femoral condyle (MF...
متن کامل